Shūichi Nitori is a boy who wishes to be a girl while Yoshino Takatsuki is the opposite, and they both like to cross-dress as the opposite sex. As the two begin their life as middle school students, they reflect on the events of their elementary school days, during which Shūichi confessed to Yoshino, but was rejected because she was not ready for love yet. (wikipedia entry for "Hourou Musuko," Episode 1.
I am glad that anime like this exist. I really loved how they portrayed this. :) I really appreciate whomever made this anime because this is something that children need to see if they are having trouble with the inside and outside not feeling the same. I hope this anime helps people a lot! :D