Azumanga Daioh is about high school life through the eyes of six girls with unusual personalities: Chiyo (the 10-year-old genius), Osaka (the resident airhead), Sakaki (the shy one prone to cat bites), Tomo (the loose cannon), Yomi (the short-tempered one) and Kagura (the resident jock).
This is a somewhat slow and relaxed anime, but it's got a lot of witty humor and crazy stuff mixed with wacky female characters. There's also a lot of random stuff that can make you burst out laughing, and the facial expressions are hilarious. I would recommend this anime to anyone who wants to relax or watch an anime series that's not too long or too short. After all, this anime makes you smile!