Azumanga Daioh is about high school life through the eyes of six girls with unusual personalities: Chiyo (the 10-year-old genius), Osaka (the resident airhead), Sakaki (the shy one prone to cat bites), Tomo (the loose cannon), Yomi (the short-tempered one) and Kagura (the resident jock).
It is a little slow at first, but it picks up rather quick. The anime seems to be leaned toward a female audience, but anyone can enjoy its humor. Osaka, has to be one of the weirdest characters ever and that is a good thing, because she makes this anime what is is. The entire cast have personalities of their own that make them unique and likeable, even the creepy teacher that has the hots for one of the girls.